Anti-Proliferating Cell Nuclear Antigen (PCNA)

Anti-Proliferating Cell Nuclear Antigen (PCNA)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
600-401-968 100 µg - -

6 - 10 Werktage*

684,00 €
 
Protein function: Auxiliary protein of DNA polymerase delta and is involved in the control of... mehr
Produktinformationen "Anti-Proliferating Cell Nuclear Antigen (PCNA)"
Protein function: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. [The UniProt Consortium]
Schlagworte: Anti-PCNA, Anti-Cyclin, Anti-Proliferating cell nuclear antigen
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 600-401-968

Eigenschaften

Anwendung: ELISA, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: synthetic peptide corresponding to an internal region of human PCNA protein.

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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