Anti-PRNP (PrP27-30, PrP33-35C,CD230)

PRNP(prion protein), also known as CD230 and PRP, is a protein that in humans is encoded by the , PRNP gene. The major prion protein is expressed in the brain and several other tissues. Expression is , most predominant in the nervous system but occurs in many other tissues throughout the body. Puckett , et al. (1991)identified a RFLP with a high degree of heterozygosity in the 5-prime region of the PRNP , gene, which might serve as a useful marker for the pter-p12 region of chromosome 20.PRNP is , associated with a variety of cognitive deficiencies and neurodegenerative diseases such as , Creutzfeldt-Jakob disease, bovine spongiform encephalopathy, and kuru. PRNP is highly conserved , through mammals, lending credence to application of conclusions from test animals such as mice., Comparison between primates is especially similar, ranging from 92.9-99.6% similarity in amino acid , sequences. , UniProt Number: P04925, Gene ID: PRNP, Applications: Suitable for use in Western Blot and Immunohistochemistry (Paraffin). Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Handling: Store at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term., Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.