Anti-PEN2 (Gamma-secretase Subunit PEN-2, Presenilin Enhancer Protein 2, PSENEN, MDS033)

Presenilin enhancer protein 2 (PEN-2) is a part of a gamma-secreted complex which catalyses the final cleavage of amyloid precursor protein to generate the toxic amyloid beta protein, the major component of plaque in the brains of Alzheimer disease patients. It is an essential subunit of the gamma-secretase complex, and an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). And probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 3-7ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: Human and mouse intestine lysate, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.