Anti-PARP11

Poly(ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly(ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors, a process that, when repeated multiple times, leads to the formation of poly(ADPribose) chains on the protein. Protein function: Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis. In vitro, exhibits mono(ADP-ribosyl) transferase activity (PubMed:25673562). [The UniProt Consortium]