Anti- MUC4

Anti- MUC4
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-11-7579-25 25 µg -

3 - 11 Werktage*

134,00 €
 
Protein function: May play a role in tumor progression. Ability to promote tumor growth may be... mehr
Produktinformationen "Anti- MUC4"
Protein function: May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelial cells segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. [The UniProt Consortium]
Schlagworte: Anti-MUC4, Polyclonal Antibody to  MUC4
Hersteller: Abeomics
Hersteller-Nr: 11-7579-25

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: A partial length recombinant MUC4 protein (amino acids 1700-1960) was used as the immunogen for this antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti- MUC4"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen