Anti-Mouse IFN gamma NALE(TM) Purified (Clone: XMG1.2)

The XMG1.2 is a neutralizing antibody that binds with the mouse Interferon-gamma (IFN-Gamma) protein, a 15 -17 kDa cytokine with significant antibacterial, antiviral, and antitumoral properties. When secreted by natural killer cells and by natural killer T lymphocytes, it regulates the immune response and supports adaptive immunity when produced by Th1 or CD8+ T lymphocytes. IFN-Gamma plays an important role in the activation, the growth, and the differentiation of the macrophages, B and T lymphocytes, and natural killer cells. It interacts synergically with other cytokines, such as TNF-Alpha, to inhibit proliferation of normal and transformed cells. IFN- Gamma is the primary cytokine that defines Th-1 cells.The biological activity of IFN-Gamma is not affected by glycosylation. Protein function: Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. [The UniProt Consortium]