Anti-Mouse EBI3 (Clone: ABM2C40)

Epstein-Barr Virus Induced Gene 3 (EBI3) is an immune regulator that has been associated with the pathogenesis of inflammatory bowel disease. EBI3, as part of the immunosuppressive IL-35 cytokine, plays an important role in the regulation of intestinal immune responses by controlling overwhelming T-cell activation. EBI3 deficiency does not lead to changes in intestinal pathology in trinitrobenzene sulfonic acid colitis, but is protective in oxazolone-induced colitis. Protein function: Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. [The UniProt Consortium]