Anti-Mouse CD3 (Clone: 145-2C11)

Anti-Mouse CD3 (Clone: 145-2C11)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-10-4123-25 25 µg -

3 - 11 Werktage*

102,00 €
 
CD3 is one of the several invariant chains that the variable chains of TCR: Alpha beta or Gamma... mehr
Produktinformationen "Anti-Mouse CD3 (Clone: 145-2C11)"
CD3 is one of the several invariant chains that the variable chains of TCR: Alpha beta or Gamma delta TCR contains, and which support surface TCR expression and transduce the TCR signal. CD3D, along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity- dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN). [The UniProt Consortium]
Schlagworte: Anti-Cd3z, Anti-Cd247, Anti-CD247, Anti-T-cell receptor T3 zeta chain, Anti-T-cell surface glycoprotein CD3 zeta chain, Monoclonal Antibody to Mouse CD3 (Clone: 145-2C11)
Hersteller: Abeomics
Hersteller-Nr: 10-4123-25

Eigenschaften

Anwendung: FC
Antikörper-Typ: Monoclonal
Klon: 145-2C11
Konjugat: No
Wirt: Hamster
Spezies-Reaktivität: mouse
Immunogen: Mouse BM10-37 cytotoxic T lymphocytes were used as immunogen for this antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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