Anti-Mouse CD28 NALE(TM) Purified (Clone: 37.51)

The 37.51 monoclonal antibody specifically reacts with mouse CD28 molecule, a 45 kDa homodimer. It is expressed on most thymocytes, at low density on most of the CD4+ and CD8+ peripheral T lymphocytes and on the natural killer cells. It is additionally found on activated splenocytes, mast cells, and thymocytes. CD28 is a costimulator of T lymphocytes and a ligand for CD80 (B7-1), and CD86 (B7-2). The CD28 signaling stimulates the expression of IL-2 and IL-2 receptor and the cytotoxicity of CD3-activated T lymphocytes. The 37.51 antibody stimulates the proliferation of T lymphocytes and natural killer cells and their respective cytokine production. Protein function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. [The UniProt Consortium]