Anti-MITF, clone 21D1418

Anti-MITF Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with MITF from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-MITF from other sources has not been determined. Protein function: Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'- CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. [The UniProt Consortium]