Anti-MIB1

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
600-401-CU3 100 µg - -

6 - 10 Werktage*

684,00 €
 
Anti-MIB1 antibody was affinity purified from monospecific antiserum by immunoaffinity... mehr
Produktinformationen "Anti-MIB1"
Anti-MIB1 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. MIB1 antibody is human, mouse and rat reactive. At least three isoforms of MIB1 are known to exist. Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF- induced apoptosis. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. [The UniProt Consortium]
Schlagworte: Anti-DIP1, Anti-MIB1, Anti-DIP-1, EC=6.3.2.-, Anti-Mind bomb homolog 1, Anti-DAPK-interacting protein 1, Anti-E3 ubiquitin-protein ligase MIB1, Anti-Zinc finger ZZ type with ankyrin repeat domain protein 2
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 600-401-CU3

Eigenschaften

Anwendung: ELISA, IFM, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: 19 amino acid peptide near the C-terminus of human MIB1.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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