Anti-MEK1 C-Term, clone 13B6.G12

Anti-MEK1 C-Term, clone 13B6.G12
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
200-301-GQ0 100 µg - -

6 - 10 Werktage*

698,00 €
 
This protein A purified mouse monoclonal antibody reacts specifically with human MEK1. Anti-MEK1... mehr
Produktinformationen "Anti-MEK1 C-Term, clone 13B6.G12"
This protein A purified mouse monoclonal antibody reacts specifically with human MEK1. Anti-MEK1 is purified from tissue culture supernatant by protein A purification. Cross reactivity is expected to occur with human, mouse, and rat based on sequence identity of the peptide immunogen. This antibody does not react with the MEK2 isoform. Protein function: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator- activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. [The UniProt Consortium]
Schlagworte: Anti-MEK1, Anti-MKK1, Anti-MEK 1, Anti-MAP2K1, Anti-MAPKK 1, EC=2.7.12.2, Anti-MAPK/ERK kinase 1, Anti-MAP kinase kinase 1, Anti-ERK activator kinase 1, Anti-Dual specificity mitogen-activated protein kinase kinase 1
Hersteller: Rockland Immunochemicals
Hersteller-Nr: 200-301-GQ0

Eigenschaften

Anwendung: ELISA, WB
Antikörper-Typ: Monoclonal
Klon: 13B6.G12
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human, mouse, rat
Immunogen: synthetic peptide corresponding to amino acid residues near the C-terminus conjugated to KLH.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-MEK1 C-Term, clone 13B6.G12"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen