Anti-MALT1, clone SPM578

1 mg/ml in sterile PBS, BSA free, sodium azide free. Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT-1) is found in extranodal low-grade B cell lymphomas. The gene encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT-1 gene and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11,18)(q21,q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT-1 caspase-like domain. MALT-1 mRNA is found in pre-B cells, mature B cells and plasma cells. Protein function: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. [The UniProt Consortium]