Anti-kB-Ras1 (Clone: ABM17B5)

KBRS1 or NKIRAS1is a protein that acts as a potent regulator of NF-kB activity by preventing degradation of NF-kB inhibitor beta (NFKBIB). KBRS1 acts by blocking phosphorylation of NFKBIB and thereby mediating cytoplasmic retention of p65/RELA NF-kB subunit. Protein function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. [The UniProt Consortium]