Anti-JAK3

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA070314.25 25 µl -

7 - 10 Werktage*

300,00 €
ATA-HPA070314.100 100 µl -

7 - 10 Werktage*

421,00 €
 
Protein function: Non-receptor tyrosine kinase involved in various processes such as cell growth,... mehr
Produktinformationen "Anti-JAK3"
Protein function: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 76% and to rat: 71%
Schlagworte: Anti-L-JAK, Anti-JAK-3, EC=2.7.10.2, Anti-Janus kinase 3, Anti-Leukocyte janus kinase, Anti-Tyrosine-protein kinase JAK3
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA070314

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: ETFHVGLPGA LGGHDGLGLL RVAGDGGIAW TQGEQEVLQP FCDFPEIVDI SIKQAPRVGP AGEHRLVTVT RTDNQILEAE FPGL (ATA-APrEST88635)

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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