Anti-IRE1p

Anti-IRE1p Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with IRE1p from other sources has not been determined. Protein function: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. [The UniProt Consortium]