Anti-IMPDHII

Anti-IMPDHII
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-11-3028-100 100 µg -

3 - 11 Werktage*

387,00 €
 
Human type II inosine monophosphate dehydrogenase (IMPDHII) is a key enzyme in the purine... mehr
Produktinformationen "Anti-IMPDHII"
Human type II inosine monophosphate dehydrogenase (IMPDHII) is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. It is linked to cell growth, differentiation, and malignant transformation. IMPDHII also plays an important role in the negative regulation of TLR2 signaling by modulating PI3K activity. Indeed, IMPDHII increases the phosphatase activity of SHP1, which participates in the inactivation of PI3K. Enhanced expression of IMPDHII promotes the tumor metastasis and the advanced tumor progression in patients with prostate cancer. Protein function: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. [The UniProt Consortium]
Schlagworte: Anti-IMPD2, Anti-IMPD 2, Anti-IMPDH 2, Anti-IMPDH-II, Anti-IMP dehydrogenase 2, Anti-Inosine-5'-monophosphate dehydrogenase 2, Polyclonal Antibody to IMPDHII
Hersteller: Abeomics
Hersteller-Nr: 11-3028

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human (Erwartet: mouse)
Immunogen: A partial length recombinant IMPDHII protein (amino acids 86-291) was used as the immunogen for this antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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