Anti-IL-8

Anti-IL 8 antiserum has been heated to 56°C for 30 minutes.  The antiserum detects recombinant and native IL-8 present in body fluids and cell supernatants in ELISA.  Although likely to be functional, this antiserum has not been evaluated in other assays, including neutralization and immunohistochemistry. Protein function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. [The UniProt Consortium]