Anti-IL-37

Anti-IL-37 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. IL-37 antibody is human specific. Multiple isoforms of IL-37 are known to exist, this antibody will only detect the largest isoform. IL-37 antibody is predicted to not cross-react with IL-36. Protein function: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. [The UniProt Consortium]