Anti-HLA-DM (beta chain)

Anti-HLA-DM (beta chain)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-R30885 100 µg - -

3 - 10 Werktage*

755,00 €
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Major histocompatibility complex, class... mehr
Produktinformationen "Anti-HLA-DM (beta chain)"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Major histocompatibility complex, class II, DM beta, also known as D6S221E, RING7, HLA-DM histocompatibility type, beta chain, HLADMB or RING7, is a protein that in humans is encoded by the HLADMB gene. HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chains, both anchored in the membrane. It is located in intracellular vesicles. The protein plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. HLA-DMA and -DMB appear to encode subunits of a functional heterodimer that is critical in the pathway of class II antigen presentation. Protein function: Plays a critical role in catalyzing the release of class II- associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. [The UniProt Consortium]
Schlagworte: Anti-DMB, Anti-HLA-DMB, Anti-MHC class II antigen DMB, Anti-Really interesting new gene 7 protein, Anti-HLA class II histocompatibility antigen, DM beta chain, HLA-DM Antibody (beta chain)
Hersteller: NSJ Bioreagents
Hersteller-Nr: R30885

Eigenschaften

Anwendung: WB, IHC (paraffin)
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human
Immunogen: Amino acid sequence from the middle region of human HLA-DM beta chain (NQKDTLMQRLRNGLQNCATH)
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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