Anti-Histone H2BK23Ac Monoclonal Antibody (Clone RM260)

Histone H2B is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei. It is a globular protein that contains a histone fold domain with a C-terminal alpha-helix that facilitates nucleosome interactions and chromatin compaction, as well as an unstructured N-terminal tail that extends outside of the nucleosome core, both of which are subject to various post-translational modifications (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation. Histone H2B is subject to acetylation at lysine 23 (H2BK23Ac). Cayman's Histone H2BK23Ac Monoclonal Antibody (Clone RM260) can be used for ELISA, immunocytochemistry (ICC), multiplex-based assays, and Western blot (WB) applications.Synonyms: Acetylated Histone H2B Lysine 23. Immunogen: Peptide corresponding to H2BK23Ac. Clone Designation: RM260. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ELISA, ICC, multiplex-based assays, WB. Cross Reactivity: (+) H2BK23Ac, (-) Unmodified H2BK23, (-) H2BK5Ac, (-) H2BK11Ac, (-) H2BK12Ac, (-) H2BK15Ac, (-) H2BK16Ac, (-) H2BK20Ac.