Anti-Hemoglobin beta C, clone 15C2.C11.F2.G1

This protein A purified mouse monoclonal antibody reacts specifically with human HbC beta c-variant isoform. Anti-HbC is purified from tissue culture supernatant by protein A purification. This antibody does not react with the HbA, HbS, HbF, or HbA-2 isoforms. HbC antibodies detect the E6K mutant in the hemoglobin beta subunit. Functional hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (alpha2beta2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA2. Sickle cell disease (SCD), thalassemias and hemoglobinopathies occur when aberrant forms of hemoglobin are expressed in children and adults. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Less significant than the SCD-E6V, HbC E6K mutation causes a mild hemolytic anemia. HbC antibody does not react to other forms of Hb. This antibody is ideal for investigators involved in Cardiovascular and developmental biology research.