Anti-GRK2

This affinity purified antibody is directed against human GRK2. This product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis of the sequence shows 100% reactivity to human, and 90% to rat, mouse, and golden hamster. Protein function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)- dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity. [The UniProt Consortium]