Anti-GAPDH, clone RM114

Anti-GAPDH, clone RM114
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-R20198BTN-50UL 50 µl - -

3 - 10 Werktage*

737,00 €
 
Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. This recombinant GAPDH antibody... mehr
Produktinformationen "Anti-GAPDH, clone RM114"
Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. This recombinant GAPDH antibody reacts to Glyceraldehyde 3-phosphate dehydrogenase. Protein function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively (PubMed:3170585, PubMed:11724794). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D- glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (PubMed:3170585, PubMed:11724794). Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1- dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). Also plays a role in innate immunity by promoting TNF-induced NF-kappa-B activation and type I interferon production, via interaction with TRAF2 and TRAF3, respectively (PubMed:23332158, PubMed:27387501). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. [The UniProt Consortium]
Schlagworte: Anti-GAPDH, Anti-CDABP0047, Anti-Peptidyl-cysteine S-nitrosylase GAPDH, Anti-Glyceraldehyde-3-phosphate dehydrogenase, GAPDH Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: R20198BTN

Eigenschaften

Anwendung: WB, IP, ICC, IHC, ChIP
Antikörper-Typ: Monoclonal
Klon: RM114
Konjugat: No
Wirt: Rabbit
Immunogen: A peptide corresponding to the C-terminus of GAPDH
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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