Anti-FKBP12

Anti-FKBP12 antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. FKBP12 antibody is human, mouse and rat reactive. Protein function: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [The UniProt Consortium]