Anti-Fibrinogen (alpha chain) Monoclonal Antibody (Clone 6D6)

Fibrinogen is a hexameric glycoprotein that has roles in coagulation and hemostasis. It is comprised of two sets of Aalpha, Bbeta, and gamma polypeptide chains encoded by FGA, FGB, and FGG, respectively, in humans. Fibrinogen is synthesized in hepatocytes and secreted into the plasma. Following thrombin-mediated cleavage of N-terminal fibrinopeptides from the Aalpha and Bbeta chains, yielding the alpha and beta chains, respectively, fibrinogen assembles into fibrin protofibrils and then mature fibers, which provide structure and viscoelasticity to blood clots. Mutations in FGA, FGB, or FGG have been found in patients with afibrinogenemia or hypofibrinogenemia. Elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular disease. Immune complexes containing citrullinated fibrinogen have been found in patients with anti-citrullinated protein antibody-positive rheumatoid arthritis. Cayman's Fibrinogen (alpha chain) Monoclonal Antibody (Clone 6D6) can be used for Western blot (WB) applications. The antibody recognizes the alpha chain of fibrinogen at 70 kDa from human samples.Synonyms: FGA. Immunogen: Human fibrinogen (alpha chain). Clone Designation: 6D6. MW: 70 kDa. Formulation: (Request formulation change), 100 µg of protein G-purified antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: WB. UniProt Accession #: P02671.