Anti-DUSP13, SKRP4

DUSP13 is a member of the protein-tyrosine phosphatase superfamily which can act on both phosphotyrosine and phosphoserine/threonine residues. Two different but related isoforms are reported, viz., A and B. DUSP13 gene encodes different but related DSP proteins through the use of non-overlapping ORFs and alternate splicing. DUSP13A has been implicated in MAP3K5/ASK1-mediated apoptosis. The B isoform dephosphorylates MAPK8/JNK and MAPK14/p38. This protein has been implicated in postnatal development of specific tissues. Protein function: Probable protein tyrosine phosphatase. Has phosphatase activity with synthetic substrates (PubMed:15252030, PubMed:29106959). Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1. [The UniProt Consortium]