Anti-DUSP13

0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. DUSP13 is a dual specificity phosphatase (DSP), dephosphorylating tyrosine and serine/threonine residues, and is expressed in two forms. DUSP13B, or testis and skeletal muscle-specific dual specificity phosphatase (TMDP), has been shown inhibit MAPK activation and AP-1-dependent gene expression. DUSP13A, or muscle-restricted dual specificity phosphatase (MDSP), does not display either of these functions. Protein function: Probable protein tyrosine phosphatase. Has a phosphatase activity-independent regulatory role in MAP3K5/ASK1-mediated apoptosis, preventing MAP3K5/ASK1 inhibition by AKT1. Shows no phosphatase activity on MAPK1/ERK2, MAPK8/JNK, MAPK14/p38 and MAP3K5/ASK1. [The UniProt Consortium]