Anti-Delta2 alpha-Tubulin Rabbit Monoclonal Antibody (Clone RM447)

Delta2 alpha-Tubulin is a non-tyrosinatable variant of tubulin that lacks a carboxy-terminal glutamyl-tyrosine group on its alpha-subunit. It is expressed in a wide variety of cell types, including fibroblasts and adrenal cortical cells, and accounts for approximately 35% of brain tubulin. Delta2 alpha-Tubulin is primarily localized to stable cellular structures such as centrosomes and primary cilia, however, it localizes to microtubule bundles and paracrystalline bundles following cellular exposure to paclitaxel or vinblastine, respectively. It is also subject to post-translational modifications, including glutamylation, and levels of glutamylated Delta2 alpha-tubulin are increased in mouse models of acute epileptic seizure and slow-developing Alzheimer's disease. Cayman's Delta2 alpha-Tubulin Rabbit Monoclonal Antibody (Clone RM447) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Immunogen: Peptide corresponding to human Delta2 alpha-tubulin. Clone Designation: RM447. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) Delta2 alpha-Tubulin.