Anti-CXCR4

Protein function: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). Involved in the AKT signaling cascade (PubMed:24912431). Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). Acts as a receptor for extracellular ubiquitin, leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059). Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. {ECO:0000250, UniProtKB:P70658, ECO:0000269, PubMed:10074102, ECO:0000269, PubMed:10452968, ECO:0000269, PubMed:10644702, ECO:0000269, PubMed:10825158, ECO:0000269, PubMed:11276205, ECO:0000269, PubMed:17197449, ECO:0000269, PubMed:18799424, ECO:0000269, PubMed:20048153, ECO:0000269, PubMed:20228059, ECO:0000269, PubMed:20505072, ECO:0000269, PubMed:24912431, ECO:0000269, PubMed:28978524, ECO:0000269, PubMed:8752280, ECO:0000269, PubMed:8752281}. [The UniProt Consortium]