Anti-CXCR2

Anti-CXCR2 antibody is directed against human CXCR2 protein.  The product was affinity purified from monospecific antiserum by immunoaffinity purification.  A BLAST analysis was used to suggest reactivity with this protein from human and mouse based on homology for the immunogen sequence.  Cross reactivity with CXCR2 from other sources has not been determined. Protein function: Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. [The UniProt Consortium]