Anti-CXCL9 (MIG) (swine)

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family. It is also commonly known as Monokine Induced by Gamma interferon (MIG). CXCL9 (MIG) is a T-cell chemoattractant, which is induced by IFN-gamma. It is closely related to two other CXC chemokines -CXCL10 and CXCL11. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL9 (MIG) elicits its effects by binding to the cell surface chemokine receptor CXCR3.