Anti-COBRA1

Cofactor of BRCA1 (COBRA1), also known as negative elongation factor B (NELFB), is a 580-amino acid nuclear protein encoded by NELFB in humans. It induces chromosome decondensation by targeting lac operator-containing chromosome regions and is a component of NELF, a four-subunit complex that suppresses RNA polymerase II elongation in vitro. COBRA1 protein levels are enriched in mammary gland luminal epithelium, and it has a role in modulating estrogen-dependent and -independent expression of oncogenes in various breast cancer cell lines. Ectopic expression or knockdown of NELFB suppresses or accelerates breast cancer cell growth, respectively, as well as enhances androgen-mediated transcription. COBRA1 also interacts with the activated protein-1 (AP-1) family members c-Jun and c-Fos, and inhibits AP-1-mediated transcription in vitro. Cayman's COBRA1 Monoclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes COBRA1 at approximately 62 kDa from human, mouse, and rat samples.Synonyms: Cofactor of BRCA1, Negative Elongation Factor B, Negative Elongation Factor Complex Member B, Negative Elongation Factor Protein B, NELF-B. Immunogen: Recombinant human full-length COBRA1 expressed in E. coli. MW: ~62 kDa. Formulation: (Request formulation change), 100 µl of protein G-purified mouse monoclonal antibody. Storage Buffer: PBS with 0.05% sodium azide. Host: Mouse. Applications: WB.