Artikelnummer | Größe | Datenblatt | Manual | SDB | Lieferzeit | Menge | Preis |
---|---|---|---|---|---|---|---|
ARG66316.100 | 100 µl | - | - |
6 - 14 Werktage* |
624,00 €
|
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Größere Menge gewünscht? Bulk-Anfrage
Protein function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. [The UniProt Consortium]
Schlagworte: | Anti-CDK4, Anti-PSK-J3, EC=2.7.11.22, Anti-Cyclin-dependent kinase 4, Anti-Cell division protein kinase 4 |
Hersteller: | Arigo Biolaboratories |
Hersteller-Nr: | ARG66316 |
Eigenschaften
Anwendung: | FC, ICC, IF, IHC (paraffin), IP, WB |
Antikörper-Typ: | Monoclonal |
Klon: | SQab1864 |
Konjugat: | No |
Wirt: | Rabbit |
Spezies-Reaktivität: | human |
Immunogen: | Synthetic peptide around the C-terminus of CDK4 |
MW: | 34 kD |
Format: | Purified |
Datenbank Information
KEGG ID : | K02089 | Passende Produkte |
UniProt ID : | P11802 | Passende Produkte |
Gene ID | GeneID 1019 | Passende Produkte |
Handhabung & Sicherheit
Lagerung: | -20°C |
Versand: | +4°C (International: +4°C) |
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!