Anti-CD44 (human), clone BU52 (F(ab')2)

Immunoglobulin was enzymatically cleaved using immobilized Ficin. F(ab')2 was separated from intact antibody and Fc fragments by Protein A and size exclusion chromatography. No intact antibody was observed by SDS-PAGE. Protein function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. [The UniProt Consortium]