Anti-CD36 (Clone JC63.1)

CD36, also known as scavenger receptor B2 or fatty acid translocase, is a transmembrane glycoprotein that has roles in fatty acid uptake and lipid metabolism and signaling. It is composed of N- and C-terminal cytoplasmic tails, two transmembrane domains, and an extracellular loop that binds to a variety of lipid ligands, including long-chain fatty acids, oxidized LDL, and oxidized phospholipids, and protein ligands, such as thrombospondin (TSP-1), and is subject to post-translational modifications. CD36 is expressed by a variety of cells, including hematopoietic cells such as platelets, monocytes, and macrophages, as well as adipocytes, enterocytes, cardiac and skeletal myocytes, and endothelial and epithelial cells. It also exists as a soluble form, sCD36, which is produced via plasma proteases. CD36 expression is regulated by several transcription factors, including peroxisome proliferator-activated receptor (PPAR), STAT3, and hypoxia-inducible factor-1alpha (HIF-1alpha), in a tissue-dependent manner. It is localized to the plasma membrane and within endosomes, the endoplasmic reticulum, and mitochondria, and is translocated between these compartments in response to various stimuli, including insulin-induced PI3K signaling and muscle contraction-induced AMPK signaling, to regulate fatty acid uptake. It has additional roles in the phagocytosis of apoptotic cells and P. falciparum-infected red blood cells (RBCs), angiogenesis, thrombosis, inflammation, and atherosclerosis, as well as cancer metastasis. Cayman's Scavenger Receptor B2/CD36 Monoclonal Antibody (Clone JC63.1) can be used for flow cytometry (FC) applications.Synonyms: Fatty Acid Translocase, GPIIIb, GPIV, Platelet Glycoprotein 4, PAS IV, Platelet Collagen Receptor, Thrombospondin Receptor. Immunogen: Recombinant full-length mouse CD36 expressed in adenovirus. Clone Designation: JC63.1. Formulation: (Request formulation change), 100 µg of protein L-purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol, and 0.02% sodium azide. Host: CD36 null mouse. Isotype: IgA. Applications: FC. Cross Reactivity: (+) CD36. UniProt Accession #: Q08857.