Anti-CD31 / PECAM-1 (Endothelial Cell Marker)(C31.3 + C31.7 + C31.10)

Anti-CD31 / PECAM-1 (Endothelial Cell Marker)(C31.3 + C31.7 + C31.10)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-36-1553-100 100 µg -

3 - 11 Werktage*

853,00 €
 
CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of... mehr
Produktinformationen "Anti-CD31 / PECAM-1 (Endothelial Cell Marker)(C31.3 + C31.7 + C31.10)"
CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence. Protein function: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells, PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock- induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis. [The UniProt Consortium]
Schlagworte: Anti-CD31, Anti-PECA1, Anti-GPIIA', Anti-PECAM1, Anti-EndoCAM, Anti-PECAM-1, Anti-Platelet endothelial cell adhesion molecule, Monoclonal Antibody to CD31 / PECAM-1 (Endothelial Cell Marker)(C31.3 + C31.7 + C31.10)
Hersteller: Abeomics
Hersteller-Nr: 36-1553

Eigenschaften

Anwendung: FC, IF, WB, IHC
Antikörper-Typ: Monoclonal
Klon: C31.3 + C31.7 + C31.10
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human, cynomolgus monkey, rabbit, rat
Immunogen: Human recombinant CD31 protein
Format: Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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