Anti-CD3 epsilon, clone OKT3

Anti-CD3 epsilon, clone OKT3
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-V8204SAF-100UG 100 µg - -

3 - 10 Werktage*

781,00 €
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Recognizes the epsilon-chain of CD3, which... mehr
Produktinformationen "Anti-CD3 epsilon, clone OKT3"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Recognizes the epsilon-chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. It is found on all mature T-lymphocytes, NK, T-cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. It is expressed, typically at high levels, on peripheral T cells and majority of T cell neoplasms. Thymocytes express CD3 at different level on the cell surface in the course of differentiation and, in cortical thymus, CD3 is predominantly Intracytoplasmic. This MAb has been reported to have potent immunosuppressive properties in vivo and has been proven effective in the treatment of renal, heart and liver allograft rejection. Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down- regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128). [The UniProt Consortium]
Schlagworte: Anti-T3E, Anti-CD3e, Anti-CD3E, Anti-T-cell surface glycoprotein CD3 epsilon chain, Anti-T-cell surface antigen T3/Leu-4 epsilon chain, CD3 epsilon Antibody
Hersteller: NSJ Bioreagents
Hersteller-Nr: V8204SAF

Eigenschaften

Anwendung: FC, ICC, IF, FA
Antikörper-Typ: Monoclonal
Klon: OKT3
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: Human PBMC
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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