Anti-CD22

Polyclonal Antibody against Human CD22, Gene description: CD22 molecule, Alternative Gene Names: SIGLEC-2, SIGLEC2, Validated applications: IHC, Uniprot ID: P20273, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. [The UniProt Consortium] Mouse gene identity: 56% Rat gene identity: 56%