Anti-CD2, clone 4C3

The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells. The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition. A locus control region (LCR) has been found in the 3' flanking sequence of this gene.CD2 (CD2 Molecule) is a Protein Coding gene. Diseases associated with CD2 include Penis Squamous Cell Carcinoma and Immune Defect Due To Absence Of Thymus. Among its related pathways are PEDF Induced Signaling and TGF-Beta Pathway. GO annotations related to this gene include protein homodimerization activity and receptor activity. Protein function: CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. [The UniProt Consortium]