Anti-Caspase-1 (Clone 14F468)

Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a tetramer to form the active enzyme. Caspase-1 is similar to the cell death gene CED-3 of C. elegans and regulates multiple proinflammatory cytokines, including interleukin-1beta and interferon-gamma-inducing factor.Synonyms: IL-1beta Converting Enzyme. Immunogen: synthetic peptide corresponding to human Caspase-1 within the region of amino acids 371-390. Clone Designation: 14F468. Formulation: (Request formulation change), 100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Host: Mouse. Isotype: IgG1kappa. Applications: IHC (paraffin-embedded sections) and WB.