Anti-CARM1

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABS-KC-6065.50 50 µl - -

Fragen Sie uns nach der Lieferzeit

232,00 €
ABS-KC-6065.100 100 µl - -

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332,00 €
 
Protein function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of... mehr
Produktinformationen "Anti-CARM1"
Protein function: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA- binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA- stabilizing properties and the half-life of their target mRNAs. [The UniProt Consortium]
Schlagworte: Anti-Histone-arginine methyltransferase CARM1, Anti-Coactivator-associated arginine methyltransferase 1, Anti-Protein arginine N-methyltransferase 4, CARM1 Antibody
Hersteller: Absea
Hersteller-Nr: KC-6065

Eigenschaften

Antikörper-Typ: Monoclonal
Klon: 2Q95
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human, mouse
Format: Solution

Handhabung & Sicherheit

Lagerung: -20°C (avoid repeat freezing and thawing cycles)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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