Anti-BACE

Anti-BACE Antibody is purified by ion exchange chromatography. Cross reactivity with BACE from other sources has not been determined. Protein function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. [The UniProt Consortium]