Anti-ATG4B

Anti-ATG4B antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. ATG4B antibody is human, mouse and rat reactive. At least two isoforms of ATG4B are known to exist, this antibody will detect only the larger isoform. ATG4B is predicted to not cross-react with other ATG4 proteins. Protein function: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. [The UniProt Consortium]