Anti-ATG4A

Anti-ATG4A antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. ATG4A antibody is human, mouse and rat reactive. At least two isoforms of ATG4A are known to exist, this antibody will detect both isoforms. ATG4A is predicted to not cross-react with other ATG4 proteins. Protein function: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms. [The UniProt Consortium]