Anti-ASIC3

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Acid-Sensing Ion Channel 3, also known as Testis sodium channel (TNAC1) or Dorsal root acid-sensing ion channel (DRASIC), is a protein that in humans is encoded by the ASIC3 gene. ASIC3 belongs to a family of acid-sensing channel proteins that are structurally related to epithelial sodium channel proteins and support acid-activated membrane currents. By radiation hybrid analysis, de Weille et al.(1998) mapped the gene to chromosome 7q35. De Weille et al.(1998) found that the human protein supported an H(+)-gated cation current in COS cells with kinetics similar to those of the rat protein. Babinski et al. (1999) expressed homomeric human ASIC3 channels in Xenopus oocytes and found that rapid reduction in extracellular pH resulted in a biphasic response characterized by a fast and rapidly desensitizing current followed by a slow and sustained current that returned to baseline only on return to physiologic pH. Protein function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. [The UniProt Consortium]