Anti-Angiotensin Converting Enzyme 2 (ACE-2, ACEH) Ectodomain

Angiogensin I Converting Enzyme-2 (ACE-2) is a type I transmembrane zinc protease that , cleaves angiotensins I and II to produce vasodilatory and anti-proliferative peptides. The , balance between ACE-1 and ACE-2 activity is critical for maintaining cardiovascular, renal, , and pulmonary function. ACE-2 isoforms of 75kD and 120kD are differentially expressed , between lung and kidney, respectively, and a shed soluble form is generated by , TACE/ADAM17 mediated cleavage. ACE-2 also functions as the cellular uptake receptor for , the SARS coronoavirus. Within the extracellular domain, human ACE-2 shares 83% aa , sequence identity with mouse and rat ACE-2. , , Applications: , Suitable for use in ELISA, Western Blot, Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 0.5-1.0ug/ml, Western Blot: 2ug/ml, Immunohistochemistry: 25ug/ml, Optimal dilutions to be determined by the researcher. Hybridoma: Mouse myeloma with B cells obtained from a mouse. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.