Anti-Alpha-1-Trypsin

Anti-Human ALPHA-1-ANTI-TRYPSIN Antibody was prepared from monospecific antiserum by immunoaffinity chromatography using antigen resins attached to a solid phase.   Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum.  Analysis by SDS-PAGE was used to determine that this preparation is substantially free of aggregates and shows a banding pattern consistent with purified Rabbit IgG. Protein function: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. [The UniProt Consortium]