Anti-ABCB5, clone CL12512

Monoclonal Antibody against Human TMPRSS2, Clone ID: CL12512, Gene description: Transmembrane serine protease 2, Alternative Gene Names: PRSS10, Validated applications: IHC, Uniprot ID: O15393, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C. Protein function: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia. [The UniProt Consortium] Mouse gene identity: 66% Rat gene identity: 66%