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ACHP
Artikelnummer: Cay14504-1
ACHP is an inhibitor of IkappaB kinase beta (IKKbeta) and IKKalpha (IC50s = 8.5 and 250 nM, respectively). It is selective for IKKbeta and IKKalpha over IKKgamma, Syk, and MKK4 (IC50s = >20 µM for all). It reduces the constitutive phosphorylation of IkappaBalpha and NF-kappaB p65 in U266 and NCU-MM-2 multiple...
| Schlagworte: | 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile |
| Anwendung: | IKKbeta / IKKalpha inhibitor |
| CAS | 406208-42-2 |
| MW: | 364.4 D |
ab 92,00 €
eCF506
Artikelnummer: Cay19959-1
eCF506 is an inhibitor of Src kinases (IC50s = 50 = 479 nM), as well as KIT, mTOR, PDGFRalpha, and RET (IC50s = >100 µM for all). eCF506 completely inhibits phosphorylation of Src and FAK, a downstream Src substrate, in MCF-7 and MDA-MB-231 cells when used at a concentration of 100 nM. It also inhibits proliferation...
| Schlagworte: | N-[4-[4-amino-1-[2-[4-(dimethylamino)-1-piperidinyl]ethyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-carbamic... |
| Anwendung: | Src / Fyn / Yes inhibitor |
| CAS | 1914078-41-3 |
| MW: | 510.6 D |
ab 50,00 €
Takinib
Artikelnummer: Cay24161-5
Takinib is a TGF-beta-activated kinase 1 (TAK1) inhibitor (IC50 = 9.5 nM). It is selective for TAK1 over IRAK1, IRAK4, GCK, Clk2, and MINK1 (IC50s = 390, 120, 430, 430, and 1,900 nM, respectively). Takinib increases caspase-3/-7 activity and inhibits proliferation of TNF-alpha-stimulated, but not unstimulated,...
| Schlagworte: | N1-(1-propyl-1H-benzimidazol-2-yl)-1,3-benzenedicarboxamide |
| Anwendung: | TAK1 (MAP3K7) inhibitor |
| CAS | 1111556-37-6 |
| MW: | 322.4 D |
ab 43,00 €
BIBF 1120 (esylate)
Artikelnummer: Cay31082-50
BIBF 1120 is an inhibitor of the receptor tyrosine kinases VEGFR, FGFR, and PDGFR (IC50s = 13-34, 37-610, 59, and 65 nM for VEGFR1-3, FGFR1-4, PDGFRalpha, and PDGFRbeta, respectively). It is selective for VEGFR, FGFR, and PDGFR over a panel of 33 kinases but does inhibit FLT3, LCK, LYN, and Src (IC50s = 16-156 nM)....
| Schlagworte: | Nintedanib,... |
| Anwendung: | VEGFR / FGFR / PDGFR inhibitor |
| CAS | 656247-18-6 |
| MW: | 649.8 D |
ab 66,00 €
NCL-00017509
Artikelnummer: Cay31462-1
NCL-00017509 is an inhibitor of the serine/threonine kinase Nek2 (IC50 = 56 nM).Formal Name: 3-[(6-ethynyl-9H-purin-2-yl)amino]-benzeneacetamide. CAS Number: 1507367-00-1. Molecular Formula: C15H12N6O. Formula Weight: 292.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 25...
| Schlagworte: | 3-[(6-ethynyl-9H-purin-2-yl)amino]-benzeneacetamide |
| Anwendung: | Nek2 inhibitor |
| CAS | 1507367-00-1 |
| MW: | 292.3 D |
324,00 €
TCS 21311
Artikelnummer: Cay30063-5
TCS 21311 is an inhibitor of JAK3 (IC50 = 8 nM in an enzyme assay). It is selective for JAK3 over JAK1, JAK2, and tyrosine kinase 2 (TYK2, IC50s = 1,017, 2,550, and 8,055 nM, respectively) but does inhibit glycogen synthase kinase 3beta (GSK-3beta), PKCalpha, and PKCtheta (IC50s = 13, 68, and 3 nM, respectively)....
| Schlagworte: | NIBR3049,... |
| Anwendung: | JAK3 inhibitor |
| CAS | 1260181-14-3 |
| MW: | 526.5 D |
ab 77,00 €
STO-609
Artikelnummer: Cay31358-1
STO-609 is a calcium/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor (IC50s = 120 and 40 ng/ml for CaMKKalpha and CaMKKbeta, respectively). It is selective for CaMKKs over CaMKI, CaMKII, CaMKIV, MLCK, PKC, PKA, and p42 MAPK (IC50s = >10,000 ng/ml for all). STO-609 inhibits phosphorylation of CaMKI and...
| Schlagworte: | 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid |
| Anwendung: | CaMKK inhibitor |
| CAS | 52029-86-4 |
| MW: | 314.3 D |
ab 50,00 €
AT7867
Artikelnummer: Cay16848-10
AT7867 is a potent and orally bioavailable inhibitor of Akt isoforms Akt1, 2, and 3 (IC50s = 32, 17, and 47 nM, respectively). It also inhibits p70S6 kinase and PKA (IC50s = 85 and 20 nM, respectively), but is without effect against a panel of other kinases. AT7867 inhibits growth and induces apoptosis in a variety...
| Schlagworte: | 4-(4-chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]-piperidine |
| Anwendung: | Akt Inhibitor |
| CAS | 857531-00-1 |
| MW: | 337.9 D |
ab 142,00 €
SR 3576
Artikelnummer: Cay20215-1
SR 3576 is a JNK3 inhibitor (IC50 = 7 nM). It is selective for JNK3 over JNK1 and p38 MAP kinase (IC50s = 0.17 and >20 µM, respectively). It inhibits c-Jun phosphorylation in INS-1 cells (IC50 = 1.3 µM).Formal Name: 3-[4-[[[(3-methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide....
| Schlagworte: | 3-[4-[[[(3-methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide |
| Anwendung: | JNK3 inhibitor |
| CAS | 1164153-22-3 |
| MW: | 501.5 D |
ab 43,00 €
PD 180970
Artikelnummer: Cay30619-1
PD 180970 is an inhibitor of Bcr-Abl. It inhibits wild-type and mutant forms of Bcr-Abl, as well as the p210 isoform, a marker of chronic myelogenous leukemia (CML), with IC50 values ranging from 5 to 48 nM. PD 180970 is selective for Bcr-Abl over basic FGFR (bFGFR) and PDGFR (IC50s = 934 and 1,430 nM, respectively)...
| Schlagworte: | 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one |
| Anwendung: | Bcr-Abl inhibitor |
| CAS | 287204-45-9 |
| MW: | 429.3 D |
ab 43,00 €
N-acetyl Desethylchloroquine-d4
Artikelnummer: Cay30908-1
N-acetyl Desethylchloroquine-d4 is intended for use as an internal standard for the quantification of N-acetyl desethylchloroquine by GC- or LC-MS. N-acetyl Desethylchloroquine is a minor metabolite of chloroquine (Cay-14194).Formal Name: N-[4-[(7-chloro-4-quinolinyl)amino]pentyl-1,1,2,2-d4]-N-ethyl-acetamide. CAS...
| Schlagworte: | N-acetyl-(mono) Desethylchloroquine, N-[4-[(7-chloro-4-quinolinyl)amino]pentyl-1,1,2,2-d4]-N-ethyl-acetamide |
| Anwendung: | GC-MS, LC-MS, Internal standard, Quantification |
| CAS | 1216619-20-3 |
| MW: | 337.9 D |
ab 121,00 €
Palmitoylcholine (chloride)
Artikelnummer: Cay9003456-10
Palmitoylcholine is an acyl choline. It inhibits protein kinase C activity when used at a concentration of 100 µM. Palmitoylcholine induces hemolysis in rat erythrocytes. Plasma levels of palmitoylcholine are decreased in female patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).Formal Name:...
| Schlagworte: | N,N,N-trimethyl-2-[(1-oxohexadecyl)oxy]-ethanaminium, monochloride |
| Anwendung: | Acyl choline, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) marker |
| CAS | 2932-74-3 |
| MW: | 378 D |
ab 156,00 €